学术讲座
题目:
Antimicrobial Peptide Dendrimers and Bicyclic Peptides from Chemical Space
讲座人:
Jean-Louis Reymond
Department of Chemistry and Biochemistry
University of Berne
时间:
4月25日（周四）上午10:00-12:00
地点:
卢嘉锡楼202报告厅
嘉宾介绍：
The Swiss National full professor, director of Department of chemistry and biochemistry of University of Bern, international famous medicinal chemists，deputy director of Swiss NCCR, (Royal Society of Chemistry, Chem Commun associated editor. The presenter of Chemical Space Big Data new drug discovery theory，established GDB-17 containing 166.4 billion molecular database and peptides database of PDB，Publications in Nature, JACS, PNAS, Angew Chem, etc.
讲座摘要：
There is an urgent need to develop new antimicrobial agents to fight multidrug resistant (MDR) bacteria, which represent a public health threat in the hospital environment worldwide. My group focuses on Gram-negative MDR strains of Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae, which are particularly problematic. In this lecture, I will discuss the experiments that led us from our initial studies with antibiofilm dendrimer agents identified by combinatorial chemistry approaches, to our latest antimicrobial peptide dendrimers cyclic and bicyclic peptides identified using an innovative chemical space guided discovery strategy. I will also discuss structure-function relationships in our peptide dendrimers and bicyclic peptides.
jxf吉祥官网总站
2019年4月9日
